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| 破骨细胞相关受体研究进展 |
| Research progress in osteoclast-associated receptors |
| 投稿时间：2013-04-09 |
| DOI： |
| 中文关键词: 破骨细胞相关受体 破骨细胞 骨代谢 |
| 英文关键词:Osteoclast-associated receptor Osteoclasts Bone metabolism |
| 基金项目: |
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| 摘要点击次数: 2074 |
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| 中文摘要: |
| 人破骨细胞相关受体是一种细胞表面分子，属白细胞受体复合物编码的家族成员，广泛表达于破骨细胞、单核细胞、巨噬细胞、单核源树突状细胞等髓系来源细胞，与破骨细胞分化过程中的重要调控因子相互作用，参与破骨细胞分化，在骨代谢中发挥重要作用，受多种因素调节。同时，破骨细胞相关受体与Fc受体γ链特异性结合，调节免疫反应。 |
| 英文摘要: |
| Osteoclast-associated receptors, kind of cell surface molecules, are novel members of the leukocyte receptor complex (LRC)-encoded family.The osteoclast-associated receptors are wildely expressed in osteoclasts, monocytes, macrophages, and monocyte-derived dendritic cells.They also play an important role in osteoclastogenesis through the interaction with essential regulatory factors, and participate in bone metabolism regulated by various factors.The osteoclast-associated receptors can bind with theγchain of Fc receptor specificly, thus regulating the immune response. |
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