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| 高寒地区高血压患者血清25羟维生素D3水平与颈动脉狭窄程度相关性研究 |
| Correlation between serum 25 hydroxy vitamin D3 level and severity of carotid stenosis in hypertension patients in alpine region |
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| DOI：10.3969/j.issn.1006.7108.2017.09.020 |
| 中文关键词: 高寒地区 高血压病 颈动脉狭窄 维生素D缺乏 |
| 英文关键词:Alpine region Hypertensive disease Carotid artery stenosis Vitamin D deficiency |
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| 中文摘要: |
| 目的 探讨高寒地区高血压患者颈动脉狭窄程度与血清25羟维生素D3相关性。方法 对230例长期生活在呼伦贝尔地区的原发性高血压患者行颈动脉彩色多普勒超声检查，分为正常组63例、斑块组136例和狭窄组31例，应用半定量积分判断颈动脉狭窄程度。测定血清25羟维生素D3水平，按照25羟维生素D3四分位数分为：Q1组（<7.47 ng/mL）58例，Q2（7.47~13.78）ng/mL 57例，Q3组（13.79~21.04）ng/mL 57例，Q4组（>21.04 ng/mL）58例。结果 正常组与斑块组、狭窄组25羟维生素D3比较，差异具有统计学意义[（23.77±12.23）vs（13.77±8.92），P=0.000**]、[（23.77±12.23）vs（9.18±9.79），P=0.000**]，斑块组与狭窄组比较，差异同样具有统计学意义[（13.77±8.92）vs（9.18±9.79），P=0.012*]；Q1组、Q2组、Q3组与Q4组颈动脉斑块积分比较，差异有统计学意义（P<0.05, P<0.01）。血清25羟维生素D3与颈动脉斑块积分呈负相关（r= –0.396，P=0.000）。多元logistic回归分析显示，血清25羟维生素D3是高寒地区高血压患者颈动脉斑块、狭窄独立保护因素（P<0.05，P<0.01）。结论 低水平25羟维生素D3与高寒地区高血压患者颈动脉狭窄程度相关。 |
| 英文摘要: |
| Objective To investigate the correlation between serum 25 hydroxy vitamin D3 level and severity of carotid stenosis in hypertension patients in alpine region. Methods A total of 230 Hulunbeier region residential patients with primary hypertension were recruited in this study and received carotid artery color Doppler ultrasound examination. According to the severity of carotid stenosis by semi-quantitative scoring, subjects were categorized into control group (63 cases), plaque group (136 cases), and stenosis group (31 cases). Subjects were further divided into 4 groups based on the quartitles of 25 hydroxy vitamin D3 levels. There were 58 cases in Q1 group (<7.47 ng/mL), 57 cases in Q2 group (7.47-13.78l ng/mL), 57 cases in Q3 group (13.79-21.04 ng/mL), and 58 cases in Q4 group (>21.04 ng/mL). Results The level of 25 hydroxy vitamin D3 in control group was statistically different comparing to that in plaque group (23.77±12.23 vs 13.77±8.92, P=0.000) and stenosis group (23.77±12.23 vs 9.18±9.79, P=0.000). Significant difference was also observed between plaque group and stenosis group (13.77±8.92 vs 9.18±9.79, P=0.012). The difference of stenosis scores among Q1 group, Q2 group, Q3 group, and Q4 group was significant (P<0.05, P<0.01). Serum 25 hydroxy vitamin D3 level was negatively correlated to plaque scores (r=-0.396, P=0.000. Multiple logistic regression analysis indicated that serum 25 hydroxy vitamin D3 level was the independent protective factor for carotid plaques and stenosis in hypertension patients in alpine region. Conclusion The low level of 25 hydroxy vitamin D3 is related to severity of carotid stenosis in hypertension patients in alpine region. |
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