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| 雌激素与雌激素受体骨代谢调节作用 |
| Estrogen and estrogen receptors on bone metabolism regulation |
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| DOI：10.3969/j.issn.1006-7108.2019.05.025 |
| 中文关键词: 雌激素 绝经后骨质疏松症 择性雌激素受体调节剂 雌激素受体 骨代谢 |
| 英文关键词:estrogen postmenopausal osteoporosis selective estrogen receptor modulators estrogen receptor bone metabolism |
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| 中文摘要: |
| 雌激素缺乏是绝经后骨质疏松症发生的主要原因，雌激素或雌激素受体调节剂与雌激素受体结合后通过多种分子生物学机制，抑制破骨细胞骨吸收，促进成骨细胞骨形成、提高骨密度，达到治疗绝经后骨质疏松症的目的。本文综述了雌激素、选择性雌激素受体调节剂与雌激素受体相互作用对骨代谢的调节机制、雌激素治疗骨质疏松症的动物实验研究以及雌激素治疗骨质疏松症的临床研究进展，旨在为临床骨质疏松治疗策略提供科学依据。 |
| 英文摘要: |
| Estrogen deficiency is the main cause of postmenopausal osteoporosis. Estrogen or estrogen receptor modulators bind to estrogen receptors and through various molecular biological mechanisms to inhibit osteoclast bone resorption, to promote osteoblast bone formation, and to increase bone mineral density, resulting in the treatment postmenopausal osteoporosis. This article reviews the regulation mechanism of estrogen, selective estrogen receptor modulators and estrogen receptors on bone metabolism, animal studies of estrogen in the treatment of osteoporosis, and clinical progress of estrogen in the treatment of osteoporosis, in order to provide a scientific basis for the treatment strategy of osteoporosis. |
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