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| 健康人群血清骨钙素影响因素的研究 —— 以北京市海淀区为例 |
| A study on the influential factors of serum osteocalcin in healthy population in Beijing Haidian District |
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| DOI：10.3969/j.issn.1006.7108.2019.11.002 |
| 中文关键词: 血清骨钙素 健康人群 能量代谢 BMI |
| 英文关键词:serum osteocalcin health people energy metabolism BMI |
| 基金项目: |
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| 中文摘要: |
| 目的 了解健康人群血清OC的变化及与能量代谢的关系。 方法 根据排除标准筛选115名受试者（男60人，女55人），用电化学发光法和终点法检测血清OC，能量代谢指标水平，并分析血清OC与TC、TG、HDL-C、LDL-C、FINS、FPG、HOMA-IR之间的关系。结果 绝经后女性OC水平与男性、绝经前女性差异存在统计学意义（P＜0.05）。相关性分析中，男、女性年龄与血清OC之间均呈显著负相关（r男= –0.517和r女=–0.568）。男、女性BMI与血清OC之间均呈显著负相关（r男=–0.286和r女= –0.453）。男性HDL-C与血清OC之间呈显著正相关（rHDL-C=0.271）。女性TG与血清OC之间呈显著负相关（rTG= –0.340）；女性HDL-C与血清OC之间呈显著正相关（rHDL-C=0.275）。男性FINS、HOMA-IR与血清OC之间呈显著负相关（rFINS=–0.295，rHOMA-IR=–0.28）。女性FPG、FINS、HOMA-IR与血清OC之间无显著相关性。结论 在选取的受试者中，绝经后女性血清OC水平明显低于绝经前女性，绝经后女性出现肥胖较明显。年龄、BMI与血清OC呈显著负相关，即血清OC可能导致肥胖。血清OC与机体能量代谢相关。 |
| 英文摘要: |
| Objective To understand the change of serum osteocalcin (OC) and the relationship between OC and energy metabolism in healthy population. Methods According to the exclusion criteria, 115 subjects were selected (60 males and 55 females). The levels of serum OC and energy metabolism indicators were measured with electrochemiluminescence and end point methods. The relationship between serum OC and TC, TG, DL-C, LDL-C, FINS, FPG, and HOMA-IR was analyzed. Results OC levels between men and postmenopausal women were statistically significant (P<0.05). In correlation analysis, there was a significant negative correlation between age and serum OC in both males and females (Rmale =–0.517, Rfemale =–0.568). There was a significant negative correlation between BMI and serum OC in both males and females (Rmale = –0.286, Rfemale =–0.453). There was a significant positive correlation between HDL-C and serum OC in male subjects (RHDL-C=0.271). There was a significant negative correlation between TG and serum OC (RTG = –0.34), and a significant positive correlation between HDL-C and serum OC (RHDL-C=0.275), in female subjects. There was a significant negative correlation between FINS, HOMA-IR, and serum OC in male subjects (RFINS =–0.295, RHOMA-IR =–0.28). There was no significant correlation among FPG, FINS, HOMA-IR, and serum OC in female subjects. Conclusion Among the selected subjects, serum levels of OC in postmenopausal women are significantly lower than those in premenopausal women. Obesity is more pronounced in postmenopausal women. Age and BMI are significantly and negatively correlated with serum OC, indicating that serum OC may cause obesity. Serum OC is associated with body energy metabolism. |
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