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| 血浆凝溶胶蛋白与绝经后妇女的髋部骨密度相关性研究 |
| Correlation between serum gelsolin and hip bone mineral density in postmenopausal women |
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| DOI：10.3969/j.issn.1006.7108.2019.11.003 |
| 中文关键词: 绝经后妇女 骨质疏松症 骨密度 血浆凝溶胶蛋白 |
| 英文关键词:plasma gelsolin bone mineral density postmenopausal women osteoporosis |
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| 中文摘要: |
| 目的 探索血浆凝溶胶蛋白(GSN)水平与中国人群的髋部骨密度(BMD)相关性。方法我院就诊的患者(>55岁)为研究组(A组)，按照是否患有骨质疏松症分为骨质疏松症组(OP组，BMD T评分≤–2.5)和BMD正常组 (NBMD组，BMD T评分≥–1)两组；随后将所有女性患者分为小于70岁(B组)和大于70岁(C组)两组；检测血清指标和血浆GSN水平。结果 A组中，在总受试者(P = 0.116)和男性及女性之间没有观察到血浆GSN水平的差异(P = 0.977)。Pearson相关分析显示B组和C组的血浆GSN与BMD之间呈现负相关性(r=–0.19，P =0.018)。BMD与PINP(r=–0.35，P = 0.002)、年龄(r=–0.38，P<0.001)和BMI(r =0.70，P<0.001)显著相关。GSN与BMD呈显著的负相关(r =–0.26，P=0.033)。结论 血浆GSN与中国绝经后妇女的髋部BMD密切相关，血浆GSN可能是骨质疏松症的潜在风险生物标志物。 |
| 英文摘要: |
| Objective To investigate if plasma gelsolin (GSN) protein level is associated with hip bone mineral density (BMD) in Chinese population. Methods The study group (group A) consisting of patients (>55 years old) in our hospital was divided into osteoporosis group (OP group, BMD T score ≤–2.5) and normal BMD (NBMD group, BMD T score ≥–1 at all sites). The female patients were divided to group B (less than 70 years old) and group C (older than 70 years old). Serum GSN levels were measured. Results In group A, no difference in serum GSN concentrations was observed among the total subjects (P = 0.116) and between men and women (P = 0.977). Pearson correlation analysis showed a negative correlation between serum GSN and BMD in group B and group C (r =–0.19, P = 0.081). BMD was significantly associated with PINP (r=–0.35, P = 0.002), age (r=–0.38, P<0.001), and BMI (r = 0.70, P < 0.001). There was a significant negative correlation between GSN and BMD (r =–0.26, P = 0.033). Conclusion Serum GSN is associated with hip BMD in Chinese postmenopausal women. Serum GSN might be a potential biomarker for osteoporosis risk. |
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