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| 二甲双胍对SD大鼠骨密度和体成分作用的研究 |
| Effect of metformin on bone mineral density and body composition in SD rats |
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| DOI：10.3969/j.issn.1006.7108.2020.04.008 |
| 中文关键词: 二甲双胍 骨密度 体成分 大鼠 |
| 英文关键词:metformin bone mineral density body composition rats |
| 基金项目:国家自然科学基金（81260142，8170165） |
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| 摘要点击次数: 1706 |
| 全文下载次数: 1275 |
| 中文摘要: |
| 目的 观察不同剂量二甲双胍作用不同时间对SD大鼠骨密度和体成分的影响。方法 60只3月龄SD大鼠按随机数字法分为对照组和二甲双胍100mg/(kg?d)组、200mg/(kg?d)组、300mg/(kg?d)组、500mg/(kg?d)组。每组12只。每日灌胃1次。分别于干预前，干预后4周、8周、12周测定大鼠全身骨密度及体成分。结果 干预8周和12周，不同剂量二甲双胍组骨密度均高于对照组（P＜0.05）。干预8周，不同剂量二甲双胍组骨密度均高于4周组（P＜0.05）；干预12周，二甲双胍200mg/(kg?d)组和300mg/(kg?d)组骨密度均高于8周组（P＜0.01）。干预12周，不同剂量二甲双胍干预组体重均低于对照组（P＜0.01），二甲双胍500mg/(kg?d)组体重低于100mg/(kg?d)组和200mg/(kg?d)组（P＜0.05）。干预8周，不同剂量二甲双胍组脂肪含量均低于对照组（P＜0.05）；干预12周，不同剂量二甲双胍组脂肪含量均低于对照组（P＜0.05），二甲双胍300mg/(kg?d)组脂肪含量低于100mg/(kg?d)组和200mg/(kg?d)组（P＜0.01），二甲双胍300mg/(kg?d)组和500mg/(kg?d)组脂肪含量均低于8周组（P＜0.05）。干预12周，二甲双胍200mg/(kg?d)组和300mg/(kg?d)组肌肉含量均高于对照组（P＜0.05）。结论 二甲双胍可增加SD大鼠的骨密度和肌肉含量，减少脂肪含量和减轻体重，与干预时间和剂量有关。 |
| 英文摘要: |
| Objective To investigate the effects of different doses of metformin on bone mineral density and body composition in SD rats at different treatment duration. Methods Sixty 3-month-old SD rats were randomly divided into control group, metformin 100mg/kg/day group, metformin 200mg/kg/day group, metformin 300mg/kg/day group and metformin 500mg/kg?day group. The medicine was given by gavage once a day. Bone mineral density (BMD) and body composition of rats were measured before and after intervention. Results After 8 weeks and 12 weeks intervention, BMD of rats in the metformin groups with different doses was increased compared with the control group (P < 0.05). After 8 weeks of intervention, BMD of the metformin groups with different doses was increased compared with that of the 4-week intervention groups (< 0.05). After 12 weeks of intervention, BMD of metformin group (200mg/kg?d) and group (300mg/kg?d) was higher than that of the 8-week groups (P < 0.01). After 12 weeks of intervention, weight of rats in the intervention groups with different doses of metformin was lower than that in the control group (P < 0.01). Weight of rats in the 500mg/kg?d group was lower than that in the 100mg/kg?d group and the 200mg/kg?d group (P<0.05). After 8 weeks of intervention, the fat content of rats in different doses of metformin groups was lower than that in the control group (P < 0.05). After 12 weeks of intervention, the fat content of rats in the metformin groups with different doses was lower than that in the control group (P<0.05); the fat content of rats in the metformin 300mg/kg?d group was lower than that in the metformin 100mg/kg?d group and the metformin 200mg/kg?d group (P<0.01), and the fat content of rats in the metformin 300mg/kg?d group and the metformin 500mg/kg?d group was lower than that in the 8-week groups (P<0.05). After 12 weeks of intervention, the muscle content of metformin group (200mg/kg?d) and group (300mg/kg?d) was higher than that of the control group (P<0.05). Conclusion Metformin can increase bone density and muscle content, decrease fat content and led to weight loss in SD rats, which is related to the time and dose of intervention. |
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