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| 老年2型糖尿病患者血红蛋白与骨质疏松的相关性研究 |
| The study of the association between hemoglobin and osteoporosis in older patients with type 2 diabetes |
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| DOI：10.3969/j.issn.1006-7108.2021.01.007 |
| 中文关键词: 骨质疏松 2型糖尿病 血红蛋白 贫血 |
| 英文关键词:osteoporosis type 2 diabetes mellitus hemoglobin anemia |
| 基金项目:北京市属医院科研培育计划项目（PX2020034） |
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| 中文摘要: |
| 目的 研究老年2型糖尿病（type 2 diabetes mellitus，T2DM）住院患者血红蛋白（hemoglobin，Hb）与骨质疏松的关系。方法 纳入首都医科大学宜武医院内分泌科住院的老年T2DM病例498例，测量患者的骨密度，分为骨质疏松组（160例）和非骨质疏松组（338例）。测定Hb、空腹血糖（fasting blood glucose，FBG）、糖化血红蛋白（glycosylated hemoglobin A1c，HbA1c）、25羟基维生素 D3 (25-hydroxyvitamin D3，25-OHD3)、白细胞介素6（interleukin-6，IL-6）及C反应蛋白（C-reactive protein，CRP）等。结果 骨质疏松组体质量指数（body mass index，BMI）、25-OHD3、肾小球滤过率（estimated glomerular filtration rate，eGFR）、Hb水平显著低于非骨质疏松组（P＜0.001），而年龄显著高于非骨质疏松组（P=0.017）。骨质疏松组患者贫血患病率（25.00%）显著高于非骨质疏松组（16.57%）（P=0.026）。多元Logistic回归分析显示，女性、BMI、Hb为骨质疏松的独立影响因素（分别为OR=3.10，P＜0.001；OR=0.86，P＜0.001；OR=0.90，P=0.018）。结论 Hb水平与老年T2DM患者骨质疏松的发生显著相关。 |
| 英文摘要: |
| Objective To study the association between hemoglobin (Hb) and osteoporosis in elder patients with type 2 diabetes mellitus (T2DM). Methods A total of 498 elder people with T2DM who admitted to the Department of Endocrinology, Xuanwu Hospital of Capital Medical University were included in the study. The participants were divided into osteoporosis group (n=160) and non-osteoporosis group (n=338) according to the measurement of the bone mineral density. The levels of Hb, fasting blood glucose (FBG), glycosylated hemoglobin A1c (HbA1c), 25-hydroxyvitamin D3 (25-OHD3), interleukin-6 (IL-6), and C-reactive protein (CRP) were measured. Results The body mass index (BMI), 25-OHD3, estimated glomerular filtration rate (eGFR), and Hb levels in the osteoporosis group were significantly lower than those in the non-osteoporosis group (P<0.001), but age was much higher in the osteoporosis group (P=0.017). The prevalence of anemia was significantly higher in the osteoporosis group (25.00% vs 16.57%, P=0.026). Multivariate logistic regression analysis showed that female, BMI, and Hb levels were independent influencing factors for osteoporosis (OR=3.10, P<0.001; OR=0.86, P<0.001; OR=0.90, P=0.018, respectively). Conclusion Hb levels are significantly associated with the occurrence of osteoporosis in elder adults with T2DM. |
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