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| 肝源性骨质疏松的发病机制研究 |
| The pathogenesis of hepatogenic osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2021.04.022 |
| 中文关键词: 肝病 骨质疏松 发病机制 |
| 英文关键词:liver disease osteoporosis pathogenesis |
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| 中文摘要: |
| 在我国，骨质疏松的患病率越来越高。临床实践中发现，肝病患者更容易发生骨质疏松，甚至进一步发展为骨质疏松性骨折，患者的生活质量大大地降低。研究显示，约30 %慢性肝病患者可发生骨折。肝源性骨质疏松的发病机制与很多因素有关，包括了糖代谢紊乱、纤维连接蛋白、胰岛素样生长因子1、各种细胞因子、维生素D的减少以及性激素的失衡等等。本文就肝病患者中发生骨量丢失的机制进行综述。 |
| 英文摘要: |
| The prevalence of osteoporosis is increasing in China over these years. It is found that patients with liver disease are more likely to develop osteoporosis, and even further to develop osteoporotic fractures, which greatly reduce the quality of life of the patients. About 40% of patients with chronic liver disease may experience a fracture. The pathogenesis of hepatogenic osteoporosis is related to many factors including disorder of carbohydrates metabolism, fibronectin, insulin-like growth factor 1, various cytokines, the decrease of vitamin D, and the imbalance of sex hormones. This article reviews the mechanism of bone loss in patients with liver disease. |
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