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| 云南省某医院骨科门诊患者血清维生素D水平检测与分析 |
| Detection and analysis of serum vitamin D levels in orthopedic outpatients in a hospital in Yunnan province |
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| DOI：10.3969/j.issn.1006-7108.2022.01.014 |
| 中文关键词: 25-羟基维生素D 维生素D 骨科门诊 |
| 英文关键词:25-hydroxyvitamin D vitamin D orthopedics outpatient |
| 基金项目:云南省科技厅科技计划项目[2018FE001(-283)] |
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| 中文摘要: |
| 目的 检测骨科门诊患者血清总25-羟基维生素D[25(OH)D]水平，分析不同性别和年龄段患者血清维生素D营养状态。方法 纳入2018年12月至2020年12月就诊于昆明市第一人民医院骨科门诊并采用化学发光法（免疫法）检查血清25(OH)D水平的2500例患者，记录患者的性别、年龄、血清25(OH)D值，以血清25(OH)D的值判定血清维生素D水平：①缺乏：25(OH)D＜20 ng/mL；②不足：20 ng/mL≤25(OH)D≤30 ng/mL；③充足：25(OH)D＞30 ng/mL。根据患者性别分为男性组和女性组，根据患者年龄分为未成年组（＜18岁）、青年组（18～43岁）、中年组（44～64岁）、老年组（≥65岁），分析骨科门诊患者不同年龄和性别与血清维生素D水平的关系。结果 所有患者中维生素D缺乏1528例（61.1%），维生素D不足830例（33.2%），维生素D充足142例（5.7%），骨科门诊患者中维生素D缺乏和不足患者占比高达94.3%，男性组患者维生素D平均值为(20.1±7.0) ng/mL，女性组维生素D平均值为(18.0±6.9) ng/mL，性别与维生素D水平之间存在显著关系，差异有统计学意义（P＜0.001）；女性维生素D水平低于男性，未成年组维生素D平均值为(17.3±7.2) ng/mL，青年组维生素D平均值为(18.4±6.6) ng/mL，中年组维生素D平均值为(18.9±6.8) ng/mL，老年组维生素D平均值为(18.4±7.5) ng/mL，年龄与维生素D水平无线性相关性（P=0.468）。结论 骨科门诊患者血清维生素D水平存在普遍缺乏和不足的现象，是骨科常见疾病的重要因素之一。 |
| 英文摘要: |
| Objective To examine the serum levels of 25-hydroxyvitamin D[25(OH)D] in orthopedic outpatients, and to analyze the status of serum vitamin D levels in patients of different gender and age. Methods A total of 2500 patients were enrolled in the orthopedic outpatient of The First Hospital of Kunming from 2018.12 to 2020.12. Their serum levels of 25-hydroxyvitamin D [25(OH)D] were examined with chemiluminescence method (immunoassay). Gender, age, and 25-hydroxyvitamin D were recorded, The level of serum vitamin D was determined according to the value of serum 25(OH)D: (1) deficient: 25(OH)D <20 ng/mL; (2) insufficient: 20 ng/mL ≤ 25(OH)D ≤ 30 ng/mL; and (3) sufficient: 25(OH)D >30 ng/mL. The patients were divided into male and female group according to their gender. According to age, the patients were divided into adolescence group (< 18 years old), youth group (18-43 years old), middle-aged group (44-64 years old), and elderly group (≥65 years old). The relationship between serum vitamin D levels and gender and age in patients of orthopedic outclinic was analyzed. Results There were 1528 cases of vitamin D deficiency (61.1%), 830 cases (33.2%) with vitamin D insufficiency, and 142 cases (5.7%) with adequate vitamin D. The proportion of vitamin D deficiency and insufficiency in the orthopedic outpatient was as high as 94.3%. The mean value of vitamin D in male group and in female group was 20.1±7.0 ng/mL and 18.0±6.9 ng/mL, respectively. There was significant relationship between gender and vitamin D, and the difference was statistically significant (P<0.001). The level of vitamin D in women was less than that in men. The mean value of vitamin D was 17.3±7.2 ng/mL in the adolescence group, 18.4±6.6 ng/mL in the youth group, 18.9±6.8 ng/mL in the middle-aged group, and 18.4±7.5 ng/mL in the elderly group, respectively. There was no correlation between age and vitamin D (P=0.468). Conclusion The level of serum vitamin D is generally deficient and insufficient in orthopedic outpatients. It is one of the important factors of common orthopedic diseases. |
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