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| 肌少-骨质疏松症动物模型及评价方法研究进展 |
| Research progress in animal models and evaluation methods of sarcopenia-osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2022.11.009 |
| 中文关键词: 肌少-骨质疏松症 动物模型 评价方法 |
| 英文关键词:sarcopenia-osteoporosis animal model evaluation method |
| 基金项目:国家自然科学基金项目（82174398）；国家重点研发计划中医药现代化研究重点专项2018年度项目（2018YFC1704301） |
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| 中文摘要: |
| 随着社会人口老龄化程度的日益加剧，肌少-骨质疏松症这类肌骨协同退变疾病的发病率逐渐增高，严重影响了老年人的身体健康，给社会医疗带来巨大负担。为了深入研究肌少-骨质疏松症的病理机制并研制有效的临床药物，构建切实有效的肌少-骨质疏松症实验动物模型至关重要。笔者综述了5种肌少-骨质疏松症模型的研究进展，即衰老肌少-骨质疏松症模型、去势肌少-骨质疏松症模型、化学诱导肌少-骨质疏松症模型、废用肌少-骨质疏松症模型以及基因肌少-骨质疏松症模型。深入探究了不同模型的研究进展、特点及应用范围，并简述了模型的评价方法，为后期肌少-骨质疏松症病理机制及临床药物的研究提供合理的动物模型。 |
| 英文摘要: |
| With the increased aging of the population, muscle and bone synergy degeneration diseases such as sarcopenia-osteoporosis is increasing, which seriously affects the health of the elderly and brings enormous burden to the social medical treatment. In order to deeply study the pathological mechanism of sarcopenia-osteoporosis and develop effective clinical drugs, it is very important to construct an effective experimental animal model of sarcopenia-osteoporosis. This paper reviews the research progress of five sarcopenia-osteoporosis models, namely aging sarcopenia-osteoporosis model, castrated sarcopenia-osteoporosis model, chemically induced sarcopenia-osteoporosis model, disused sarcopenia-osteoporosis model, and gene sarcopenia-osteoporosis model. This paper deeply explores the research progress, characteristics, and application scope of different models, and briefly describes the evaluation methods of models, so as to provide a reasonable animal model for the study of pathological mechanism and clinical drugs of late sarcopenia-osteoporosis. |
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