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| 孟德尔随机化探索骨密度与膝关节骨性关节炎的因果关联 |
| Associations of bone mineral density with knee osteoarthritis: A Mendelian randomization study |
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| DOI：10.3969/j.issn.1006.7108.2023.04.009 |
| 中文关键词: 骨密度 膝关节骨性关节炎 孟德尔随机化 |
| 英文关键词:bone mineral density knee osteoarthritis mendelian randomization |
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| 中文摘要: |
| 目的 采用孟德尔随机化分析方法，探讨骨密度与膝关节骨性关节炎的因果关联。方法 利用全基因关联研究的数据进行分析，暴露因素为骨密度，包含全身骨密度、腰椎骨密度、股骨颈骨密度、足跟骨密度、前臂远端骨密度、前臂骨密度，结局变量为膝关节骨性关节炎。采用IVW法、MR-Egger法、WM法、Simple Mode法、Weighted Mode法进行孟德尔随机化分析，并进行异质性检验、敏感性分析、多效性分析。结果 全身骨密度IVW结果显示OR(95 %CI)为1.08(1.02~1.14)；腰椎骨密度IVW结果显示OR(95 %CI)为1.09(1.01~1.18)；股骨颈骨密度IVW结果显示OR(95 %CI)为1.15(1.04~1.28)；足跟骨密度IVW结果显示OR(95 %CI)为1.04(0.99~1.08)；前臂远端骨密度IVW结果显示OR(95 %CI)为1.07(1.00~1.15)；前臂骨密度IVW结果显示OR(95 %CI)为0.97(0.86~1.10)。全身骨密度、腰椎骨密度、股骨颈骨密度的异质性检验均不存在异常变量，敏感性分析均显示稳健，且均未发现多效性。结论 全身骨密度、腰椎骨密度、股骨颈骨密度与膝关节骨性关节炎存在因果关系，而足跟骨密度、前臂远端骨密度、前臂骨密度与膝关节骨性关节炎不存在因果关系。 |
| 英文摘要: |
| Objective To evaluate the causal relationship between bone mineral density (BMD) and knee osteoarthritis(KOA). Methods Data from gene-wide association studies were used for analysis, the exposure factor was BMD, including total body BMD, lumbar BMD, femoral neck BMD, heel BMD, ultradistal forearm BMD, and forearm BMD. The outcome variable was KOA. Mendelian randomization(MR) analysis was performed by IVW method, MR-Egger method, WM method, Simple Mode method and Weighted Mode method, and heterogeneity test, sensitivity analysis and pleiotropy test were performed. Results IVW method results showed that the whole body BMD OR was 1.08 (1.02 to 1.14), lumbar spine BMD OR was 1.09 (1.01 to 1.18), femoral neck BMD OR was 1.15 (1.04 to 1.28), heel BMD OR (95% CI) was 1.04 (0.99 to 1.08), distal forearm BMD OR (95% CI) was 1.07 (1.00 to 1.15), and OR (95% CI) for forearm BMD was 0.97 (0.86 to 1.10). Total body BMD, lumbar BMD, femoral neck BMD were no abnormal variables in the heterogeneity test, and the sensitivity analysis was robust, and no pleiotropy was found. Conclusion Total BMD, lumbar BMD, and femoral neck BMD are causally related to KOA, while heel BMD, ultradistal forearm BMD, and forearm BMD are not causally related to KOA. |
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