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| 骨质疏松症缺氧反应的纵向动力学研究进展 |
| Advances in longitudinal dynamics of hypoxic response in osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2025.09.016 |
| 中文关键词: 骨质疏松症 缺氧反应 纵向动力学 骨组织细胞 |
| 英文关键词:osteoporosis hypoxia reaction longitudinal dynamics bone tissue cells |
| 基金项目:国家自然科学基金（81960877）；甘肃省高等学校创新基金（2021A-076）；甘肃省科技计划（创新基地和人才计划）项目（21JR7RA561）；敦煌医学与转化教育部重点实验室开放基金项目(DHYX20-16)；甘肃省中医药研究中心专项开放课题（zyzx-2020-zx10）；甘肃省自然科学基金（21JR1RA267，22JR5RA582）；甘肃省教育科技创新项目（2022A-067）；甘肃省高等学校创新基金（2023A-088）；甘肃省科技计划项目重点研发计划国际科技合作类（23YFWA0005）；西北营养与环境相关疾病中医药防控协同创新中心项目（ZYXT-24-02） |
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| 中文摘要: |
| 骨质疏松症(osteoporosis，OP)是一种全身性骨骼疾病，其特征是骨量减少、骨微结构受损、骨脆性升高和易于骨折。缺氧是OP中常见的空间异质性特征，其生物学反应主要受氧依赖性酶活性降低的调节。这些酶通过其对氧的亲和力，在连续的氧传感定位中发挥作用，从而定义了它们在启动反应性和适应性细胞反应中的角色。近年来关于OP缺氧反应的纵向动力学研究进展尚未有报道。因此，该文介绍了时间依赖性缺氧反应，氧依赖性酶机制和氧依赖性酶的氧亲和力范围相关机制，并探讨了缺氧反应的纵向动力学基因与OP发病的分子调控机制，以期为进一步理解和干预OP提供参考。 |
| 英文摘要: |
| Osteoporosis (OP) is a systemic bone disorder characterized by diminished bone mass, compromised bone microstructure, heightened bone fragility, and increased susceptibility to fractures. Hypoxia, a prevalent spatial heterogeneity feature in osteoporosis, is primarily modulated by the diminished activity of oxygen-dependent enzymes. These enzymes, owing to their oxygen affinity, undergo continuous oxygen sensing, thereby delineating their pivotal role in initiating adaptive cellular responses. Despite the growing body of research in osteoporosis, the longitudinal dynamics of hypoxic response in this context remain largely unexplored. This paper aims to elucidate the time-dependent hypoxic response, the mechanistic underpinnings of oxygen-dependent enzymes, and the range of oxygen affinity associated with these enzymes. Furthermore, it delves into the longitudinal dynamics of hypoxic gene expression and the molecular regulatory mechanisms underlying osteoporosis, thus furnishing valuable insights for the comprehensive understanding and targeted intervention of osteoporosis. |
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