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| 中性粒细胞与高密度脂蛋白胆固醇比值与肌少症的相关性研究 |
| Correlation between neutrophil to high density lipoprotein cholesterol ratio and sarcopenia |
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| DOI：10.3969/j.issn.1006-7108.2026.03.007 |
| 中文关键词: 肌少症 NHR 中性粒细胞 高密度脂蛋白胆固醇 NHANES |
| 英文关键词:sarcopenia NHR neutrophils high density lipoprotein cholesterol NHANES |
| 基金项目:国家自然科学基金青年项目（82305425）；上海中医药大学科技发展项目（23KFL119,24KFL089） |
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| 中文摘要: |
| 目的 基于美国国家健康与营养调查（NHANES）数据库，探索中性粒细胞与高密度脂蛋白胆固醇比值（NHR）与肌少症之间的关系。方法 以2011—2018年NHANES数据库中的肌少症受试者为研究对象，记录人口学数据、生活方式、健康状况并计算NHR，使用加权多因素Logistics回归探索NHR与肌少症之间的关系，采用限制性立方样条（RCS）回归分析NHR与肌少症的量效关系，并通过亚组分析评估不同变量对于这一关系的影响。结果 研究共纳入9 337名受试者。基线特征分析发现，患有肌少症的受试者年龄更大，教育和PIR水平更低，患有高血压、糖尿病、高脂血症的几率更高，HDL-C水平更低，血清中性粒细胞计数更多。加权多因素Logistic回归分析发现，在未调整和调整所有混杂因素的模型中，与Q1组相比，Q3组肌少症风险的比值比均明显增高。RCS分析结果显示NHR与肌少症风险之间存在显著的非线性相关（Nonlinear P＜0.05）。亚组分析结果发现，男性NHR与肌少症的相关性高于女性。与其他种族相比，非西班牙裔黑人受试者的NHR与肌少症的发生具有更强的相关性。糖尿病、高脂血症受试者与非糖尿病、高脂血症受试者相比，NHR与肌少症之间的相关性更为显著。结论 NHR与肌少症风险之间存在正相关关系，及时监测老年人NHR有助于肌少症的早期诊断和预防干预。 |
| 英文摘要: |
| Objective To explore the relationship between the neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and sarcopenia using data from the National Health and Nutrition Examination Survey (NHANES) in the United States. Methods Subjects with sarcopenia from the NHANES database (2011-2018) were included. Demographic data, lifestyle, health status, and NHR were recorded. Weighted multivariable logistic regression was used to explore the relationship between NHR and sarcopenia. The dose-response relationship between NHR and sarcopenia was analyzed using restricted cubic spline (RCS) regression. Subgroup analyses were conducted to evaluate the impact of different variables on this relationship. Results A total of 9,337 subjects were included in the study. Baseline characteristic analysis revealed that subjects with sarcopenia were older, had lower education and PIR levels, and had higher chances of hypertension, diabetes, and hyperlipidemia. They also had lower HDL-C levels and higher serum neutrophil counts. Weighted multivariable logistic regression analysis showed that, compared to the Q1 group, the odds ratio (OR) of sarcopenia risk in the Q3 group was significantly higher in both unadjusted and fully adjusted models. The cubic spline regression analysis indicated a significant nonlinear relationship between NHR and sarcopenia risk (nonlinear P<0.05). Subgroup analysis revealed that the association between NHR and sarcopenia was stronger in men than in women. Compared to other races, non-Hispanic Black subjects showed a stronger association between NHR and sarcopenia incidence. In subjects with diabetes and hyperlipidemia, the association between NHR and sarcopenia was more significant than in those without these conditions. Conclusion There is a positive correlation between NHR and sarcopenia risk. Monitoring NHR in the elderly in a timely manner may aid in the early diagnosis and preventive intervention of sarcopenia. |
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