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| 中国新疆成人脂肪分布与骨质疏松症、肌少症和骨肌减少症的关系研究 |
| The relationship between fat distribution and osteoporosis, sarcopenia, and osteosarcopenia in adults in Xinjiang, China |
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| DOI：10.3969/j.issn.1006-7108.2026.03.013 |
| 中文关键词: 脂肪分布 骨质疏松症 肌少症 骨肌减少症 |
| 英文关键词:fat distribution osteoporosis sarcopenia osteosarcopenia |
| 基金项目:国家自然科学基金资助项目（32171151） |
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| 中文摘要: |
| 目的 旨在讨论骨质疏松症（OP）、肌少症（SP）、骨肌减少症（OS）与新疆成人躯干脂肪百分比（TFP）、上肢脂肪百分比（AFP）、下肢脂肪百分比（LFP）、内脏脂肪量（VAT）和瘦体质指数（LMI）的关系。方法 本项横断面研究纳入了新疆18岁以上的成年参与者，根据他们的临床因素分为单纯骨质疏松症组、单纯肌少症组、骨肌减少症组以及既没有骨质疏松症也没有肌少症组。使用生物电阻抗人体成分分析仪检查并提供体成分数据，用多元逻辑回归分析来检验各项体成分指标与OP、SP、OS之间的关系。结果 纳入867名女性和355名男性参与者，回归结果显示：①LMI越高的男性和女性患骨质疏松症、肌少症和骨肌减少症的几率越小。②校正协变量后，男性TFP（SP，OR 2.701，95，% CI 1.229~5.936；OS，OR 2.558，95 % CI 1.049~6.234）与肌少症和骨肌减少症呈正相关，AFP（SP，OR 0.315，95 % CI 0.175~0.569；OS，OR 0.445，95 % CI 0.242~0.819）与患肌少症和骨肌减少症的呈负相关。女性TFP（OR 0.734，95 % CI 0.567~0.951）与AFP（OR 1.169，95 % CI 1.008~1.357）与患骨质疏松症呈正相关，TFP、LFP和VAT与患骨肌减少症正相关，而AFP（OR 0.706，95 % CI 0.615~0.812）与患骨肌减少症呈负相关。结论 在新疆成人中，LMI越高患OP、SP、OS的几率越小，而脂肪分布与OP、SP、OS之间的关系错综复杂，这为骨-脂肪-肌肉组织之间的研究提供了有价值的启示。 |
| 英文摘要: |
| Objective To investigate the relationship between osteoporosis (OP) and sarcopenia (SP), osteosarcopenia (OS), trunk fat percentage (TFP), arm fat percentage (AFP), leg fat percentage (LFP), visceral fat mass (VAT), and lean body mass index (LMI) in adults in Xinjiang. Methods This cross-sectional study analyzed data from adult participants over 18 years old. These participants were categorized into four distinct groups based on their clinical factors, namely individuals without osteoporosis or sarcopenia, with osteoporosis alone, with sarcopenia alone, or with osteosarcopenia. The body composition data were examined and presented using a bioelectrical impedance body composition analyzer (BIA). Multiple logistic regression analysis was used to examine the association between various fat distribution indicators and OP, SP, and OS, and to explore the potential differences based on the gender. Results Eight hundred and sixty-seven females and 355 males participants were included. The results showed that: (1) participants with higher LMI would be less likely to suffer from OP, SP, and OS. (2) After adjusting for covariates, TFP was positively associated with SP (OR 2.701, 95% CI 1.229-5.936) and OS (OR 2.558, 95% CI 1.049-6.234), and AFP was negatively associated with SP (OR 0.315,95% CI 0.175-0.569) and OS (OR 0.445,95% CI 0.242-0.819) in men. TFP was positively associated with AFP (OR 1.169, 95% CI 1.008-1.357) and OP (OR 0.734, 95% CI 0.567-0.951) in women. TFP, LFP, and VAT were positively associated with OS. AFP was negatively associated with OS (OR 0.706, 95% CI 0.615-0.812). Conclusion Higher LMI is associated with lower odds of developing OP, SP, and OS in adults of Xinjiang. The relationship between fat distribution and OP, SP, and OS is complex, which provides valuable implications for the study of bone, fat, and muscle tissue. |
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