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| Piezo1在骨骼系统与免疫调控中的机制研究 |
| Mechanism of Piezo1 in the frontiers of skeletal system and immune regulation |
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| DOI：10.3969/j.issn.1006-7108.2026.03.019 |
| 中文关键词: Piezo1 机械敏感通道 骨骼系统 免疫调控 |
| 英文关键词:Piezo1 mechanically sensitive channel skeletal system immune regulation |
| 基金项目:贵州省科学技术厅基础研究计划[黔科合基础-ZK(2023)重点 036] |
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| 中文摘要: |
| Piezo1是一种机械敏感通道蛋白，通过感知力学刺激调控Ca2+内流，是骨骼与免疫系统交互的核心分子。在骨骼系统中，Piezo1通过激活YAP/β-catenin、NF-κB等信号通路促进成骨分化与影响骨骼，其功能异常与骨质疏松、骨关节炎及异位骨化等疾病密切相关。在免疫调控中，Piezo1通过响应力学信号与化学信号，调控巨噬细胞极化、中性粒细胞杀菌功能及T细胞分化平衡，并在炎症性疾病中发挥双向作用。进一步研究揭示，Piezo1通过介导巨噬细胞-骨髓间充质干细胞交互形成骨骼系统及免疫系统交互调控网络。尽管靶向Piezo1在骨修复、抗炎及肿瘤免疫治疗中展现潜力，但其临床转化仍受限于多种条件限制。未来研究应旨在阐明Piezo1动态调控骨骼系统及免疫系统的机制，并探索其在骨骼疾病与慢性炎症治疗中的创新应用。 |
| 英文摘要: |
| Piezo1 is a mechanically sensitive channel protein that regulates Ca2? influx by sensing mechanical stimuli and serves as a core molecule in the interaction between the skeletal and immune systems. In the skeletal system, Piezo1 promotes osteogenic differentiation and affects bone by activating signaling pathways such as YAP/β-catenin and NF-κB. Abnormal function of Piezo1 is closely related to diseases such as osteoporosis, osteoarthritis, and heterotopic ossification. In immune regulation, Piezo1 responds to mechanical and chemical signals to regulate macrophage polarization, neutrophil bactericidal function, and T cell differentiation balance, and plays a bidirectional role in inflammatory diseases. Further research has revealed that Piezo1 mediates the interaction between macrophages and bone marrow mesenchymal stem cells to form an interaction regulatory network between the skeletal and immune systems. Although targeting Piezo1 shows potential in bone repair, anti-inflammation, and tumor immunotherapy, its clinical translation is still limited by various conditions. Future in-depth research aims to achieve the dynamic regulation mechanism of Piezo1 on the skeletal and immune systems and its innovative application in the treatment of bone diseases and chronic inflammation. |
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