| Osteoarthritis (OA) is a bone metabolic disease commonly found in middle-aged and elderly people. It is mainly characterized by joint cartilage injury, bone microstructure destruction, and inflammatory response. The clinical manifestations are mainly pain, swelling, stiffness, and limited activity. In the early stage of OA, physical therapy and drug intervention are the main treatments, and there are many limitations such as multi-drug resistance and adverse reactions. With the continuous in-depth study of the mechanism of OA, relevant regulatory factors have been discovered one after another. p53 protein is an important intracellular regulatory factor, which is found to regulate the proliferation, differentiation, apoptosis, autophagy and other processes of chondrocytes in OA, indicating that the expression of p53 plays an important regulatory role in bone function and metabolism. In this paper, the pathogenesis of OA was explored through p53 mediating inflammatory factors, chondrocytes, inflammatory signaling pathways, iron death and other mechanisms, and p53 will become a new target for the treatment of bone metabolic diseases such as OA. |