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| 从“上下交病，治其中”探讨血管钙化与骨质疏松症共病研究进展 |
| The progress in the co-disease of vascular calcification and osteoporosis based on the theory of treating the middle when co-disease occurred in the upper and the lower |
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| DOI：10.3969/j.issn.1006-7108.2026.07.014 |
| 中文关键词: 上下交病，治其中 血管钙化 骨质疏松 共病 病机 |
| 英文关键词:when diseases involve both the upper and lower parts of the body, treat the middle part vascular calcification osteoporosis comorbidity pathogenesis |
| 基金项目:国家自然科学基金（82305279）；江西省中医药管理局科技计划(2023A0219) |
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| 中文摘要: |
| 本文以“上下交病，治其中”理论为指导，探讨血管钙化（vascular calcification，VC）与骨质疏松症（osteoporosis，OP）共病的病机及诊治，中医认为两者病位分属“心（上焦）”与“肾（下焦）”，脾运无力、脉络瘀阻致血管钙化，脾肾两虚、骨髓失充则致骨质流失，最终产生VC与OP共病。探本溯源，中焦脾胃失枢为两者根本病机，辨治以健脾调枢为根本，以调整心肾为纲要，治宜补虚祛邪以通络，补肾填精以充骨。基于“上下交病，治其中”理论辩治VC与OP共病，求本于中、兼顾上下，具有独特指导意义，值得进行深入探讨，以期为临床防治VC与OP共病提供新思路。 |
| 英文摘要: |
| Guided by the theory of treating the middle when the disease involves both the upper and lower parts of the body, this article explores the pathogenesis, diagnosis, and treatment of the comorbidity of vascular calcification (VC) and osteoporosis (OP). Traditional Chinese medicine believes that the locations of these two diseases belong to the heart (upper Jiao) and the kidney (lower Jiao), respectively. Weakness of transportation function of the spleen and obstruction of the blood vessels due to collateral stasis leads to vascular calcification, while deficiency of both the spleen and kidney and insufficient nourishment of the bone marrow results in bone loss, ultimately leading to the comorbidity of vascular calcification and osteoporosis. Tracing back to the origin, the loss of the pivotal function of the spleen and stomach in the middle Jiao is the fundamental pathogenesis of these two conditions. The diagnosis and treatment are based on invigorating the spleen and regulating the pivot as the fundamental approach,with adjusting the heart and kidney as the key. The treatment should focus on tonifying deficiency, expelling pathogens, and dredging collaterals, as well as tonifying the kidney and replenishing essence to nourish the bones. Guided by the theory of treating the middle when the disease involves both the upper and lower parts of the body in the diagnosis and treatment of the comorbidity of VC and OP, seeking the root cause in the middle and taking both the upper and lower parts into account has unique guiding significance and is worthy of in-depth discussion. It is expected to provide new ideas for the clinical prevention and treatment of VC and OP comorbidity. |
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