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| 应用“阴中求阳”理论论治肾虚血瘀型骨质疏松 |
| Based on the theory of ' treating Yin for Yang ' to treat osteoporosis of kidney deficiency and blood stasis type |
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| DOI：10.3969/j.issn.1006-7108.2026.07.019 |
| 中文关键词: 阴中求阳 肾虚血瘀 骨质疏松 阴阳平衡 |
| 英文关键词:treating yin for yang kidney deficiency and blood stasis osteoporosis Yin-Yang balance |
| 基金项目:浙江省自然科学基金（ZCLQ24H2701）；浙江省中医药科技计划项目（2024ZR017）；浙江省中医药科技计划项目（2025ZX318） |
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| 中文摘要: |
| 在中医学理论中，"阴中求阳"作为调和阴阳的重要法则，强调阴阳互根互用，为治疗肾虚血瘀型骨质疏松症提供了重要指导。随着我国老龄化进程加速，骨质疏松患病率持续攀升，尤以肾虚血瘀型患者居多，其本质在于肾中阴阳失衡导致"阳不化气、阴不成形"的病理状态。现代研究发现，这种阴阳失调与成骨细胞-破骨细胞功能失衡、骨髓间充质干细胞分化失衡等骨代谢异常存在显著关联。通过中国知网、PubMed等平台检索国内外文献发现，金匮肾气丸、右归丸等经典方剂，采用附子配熟地、肉桂佐山茱萸的配伍模式，既体现温补肾阳的核心治法，又通过滋阴固本实现"阴中求阳"的动态平衡。相较于单纯温阳法，"阴中求阳"疗法既能避免燥热伤阴之弊，又可破解"肾虚-血瘀-骨损"的恶性循环。本文系统阐释“阴中求阳”理论在骨代谢疾病中的应用价值，为临床构建"调阴阳、通血脉、强筋骨"的综合治疗方案提供理论依据。 |
| 英文摘要: |
| In Traditional Chinese Medicine (TCM) theory, the principle of ‘ treating yin for yang ’ , emphasizing the interdependence and mutual reinforcement of Yin and Yang, serves as a critical guideline for treating osteoporosis with kidney deficiency and blood stasis pattern. With the accelerating aging population in China, the prevalence of osteoporosis continues to rise, particularly among patients characterized by kidney deficiency and blood stasis. The core pathogenesis lies in the imbalance of Yin and Yang in the kidney, leading to a pathological state of ‘ failure of Yang to transform Qi and Yin to shape form ’. Modern studies reveal that this Yin-Yang disharmony is closely associated with bone metabolism disorders, including osteoblast-osteoclast imbalance and differentiation imbalance of bone marrow mesenchymal stem cells. Through literature retrieval from databases such as CNKI and PubMed, classical formulas like Jinkui Shenqi Wan and Yougui Wan were identified. These formulas employ herb-pairing strategies (e.g., Fuzi with Shudi, Rougui with Shanzhuyu) to warm kidney Yang while nourishing Yin, achieving dynamic balance through the ‘ Yin-nourishing and Yang-promoting ’ approach. Compared with pure Yang-tonifying methods, this therapy not only avoids the risk of dryness-heat impairing Yin but also breaks the vicious cycle of ‘ kidney deficiency–blood stasis–bone deterioration.’This paper systematically elucidates the application value of the ‘ treating yin for yang ’ theory in bone metabolic diseases, providing a theoretical foundation for constructing comprehensive clinical strategies that ‘ regulate Yin-Yang, unblock blood vessels, and strengthen bones.’ |
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