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| ALB、PA、CHE预测卧床脑卒中患者肌少症价值分析 |
| Value analysis of ALB, PA and CHE in predicting sarcopenia in bedridden stroke patients |
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| DOI：10.3969/j.issn.1006-7108.2026.08.011 |
| 中文关键词: 脑卒中 肌少症 白蛋白 前白蛋白 胆碱酯酶 |
| 英文关键词:stroke sarcopenia albumin prealbumin cholinesterase |
| 基金项目:宿迁市科技项目（SY202309） |
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| 摘要点击次数: 29 |
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| 中文摘要: |
| 目的 探究血清白蛋白（ALB）、前白蛋白（PA）、胆碱酯酶（CHE）对脑卒中长期卧床患者肌少症的的预测分析。方法 分析2021年12月至2024年12月在江苏省人民医院宿迁医院就诊的106例脑卒中长期卧床患者病历资料，根据是否合并肌少症分为肌少症组（n=63）和非肌少症组（n=43）。采用分层回归模型、多因素Logistic回归模型、E值法、限制性立方样条（RCS），并利用受试者工作特征（ROC）曲线评估预测价值。结果 肌少症组患者的血清ALB、PA、CHE水平均低于非肌少症组（P＜0.05）。卧床时间、NYHA心功能分级对血清ALB、PA、CHE水平有显著负向影响（P＜0.05）。血清ALB、PA、CHE水平与肌少症风险独立相关，且存在非线性关系（P＜0.001）。ROC分析显示，单一指标预测肌少症的AUC＜0.75，而联合检测的AUC=0.809，准确性较高。结论 血清ALB、PA、CHE水平对脑卒中长期卧床患者肌少症发生风险具有一定的预测价值，且三者与肌少症风险呈非线性关系，联合检测可提高预测准确性。 |
| 英文摘要: |
| Objective To investigate the predictive analysis of serum albumin (ALB), prealbumin (PA), and cholinesterase (CHE) on sarcopenia in long-term bedridden patients with stroke. Methods The medical records of 106 long-term bedridden patients with stroke admitted to Suqian Hospital of Jiangsu Provincial People's Hospital from December 2021 to December 2024 were analyzed. Patients were divided into a sarcopenia group (n=63) and a non-sarcopenia group (n=43) based on the presence of sarcopenia. Hierarchical regression models, multifactor logistic regression models, the E-value method, and restricted cubic splines (RCS) were performed. The predictive value was assessed using receiver operating characteristic (ROC) curves. Results Serum ALB, PA, and CHE levels were significantly lower in the sarcopenia group than in the non-sarcopenia group (P<0.05). Bed rest time and New York Heart Association (NYHA) cardiac function class had a significant negative impact on serum ALB, PA, and CHE levels (P<0.05). ALB, PA, and CHE levels were independently associated with the risk of sarcopenia, exhibiting a nonlinear relationship (P<0.001). ROC analysis showed that the area under the curve (AUC) for predicting sarcopenia with a single indicator was below 0.75, while the combined detection yielded an AUC of 0.809, indicating higher accuracy. Conclusion Serum ALB, PA, and CHE levels have a certain predictive value for the risk of sarcopenia in long-term bedridden patients with stroke, and they exhibit a nonlinear relationship with the risk of sarcopenia. Combined detection may improve the predictive accuracy. |
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