| Osteoporosis (OP) is a common skeletal disease characterized by reduced bone mass and deterioration of bone microarchitecture, and its pathogenesis is closely associated with imbalances in bone metabolism. In recent years, the role of programmed cell death in OP has attracted increasing attention. Among these forms of cell death, cuproptosis and ferroptosis, two newly identified metal ion-dependent cell death modalities, have emerged as cutting-edge areas of research in bone metabolism and the pathogenesis of osteoporosis. Cuproptosis and ferroptosis do not function as isolated pathways in osteoporosis but rather form a synergistically amplified network that collectively contributes to the development of OP. Therefore, this review explores the interplay between cuproptosis and ferroptosis in osteoporosis, including metabolic interplay, oxidative stress, metal ion homeostasis, regulatory pathways, and therapeutic strategies, with the aim of providing insights for the prevention and treatment of OP. |