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| 基质重塑相关基因7在老年骨质疏松症中的表达意义 |
| The expression of matrix remodeling associated gene 7 in elderly osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2026.09.009 |
| 中文关键词: 基质重塑相关基因7 骨质疏松症 骨折 骨转换标志物 骨密度 老年 |
| 英文关键词:matrix remodeling associated gene 7 osteoporosis fracture bone turnover marker bone mineral density elderly |
| 基金项目:河南省医学科技攻关计划联合共建项目（LHGJ20220589） |
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| 中文摘要: |
| 目的 探讨基质重塑相关基因7（MXRA7）在老年骨质疏松症（osteoporosis，OP）患者中的表达意义。方法 回顾性纳入2023年5月至2024年5月我院诊断OP老年患者102例为观察组，另选择性别和年龄相匹配的非OP健康群体100名为对照组。实时荧光定量PCR（qRT-PCR）检测入院血清MXRA7表达量，电化学发光法检测血清骨转换标志物（BTM）包括骨钙素（OC）、I型原胶原N端前肽（PINP）和I型胶原羧基端肽β特殊序列（β-CTX）水平，双能X线吸收法测量腰椎1～4、股骨颈和全髋部的骨密度值（BMD）。观察组根据指南推荐进行综合治疗并随访至少1年，统计骨折发生率。结果 观察组治疗前MXRA7表达量和BMD值显著低于对照组，而OC、PINP和β-CTX水平均显著高于对照组（P＜0.05）。Pearson检验显示，MXRA7表达量与OC、PINP和β-CTX水平呈显著负相关，与BMD值呈显著正相关（P＜0.05）。观察组随访后共记录骨折15例，发生率为14.7%。骨折亚组治疗前和治疗后血清MXRA7表达量均显著低于未骨折亚组（P＜0.05）。受试者工作特征（ROC）曲线显示，治疗前MXRA7表达量预测治疗后骨折的曲线下面积（AUC）为0.854（95%CI=0.801～0.899，P＜0.001）。结论 MXRA7表达量下降可能与老年OP的发生及严重程度密切相关，可作为预测骨折发生风险的新型标志物。 |
| 英文摘要: |
| Objective To explore the expression significance of matrix remodeling associated gene 7 (MXRA7) in elderly patients with osteoporosis (OP). Methods A total of 102 elderly patients diagnosed with OP in our hospital from May 2023 to May 2024 were included as the observation group, and 100 non-OP healthy individuals matched in gender and age were selected as the control group. Real time fluorescence quantitative PCR (qRT-PCR) was used to detect the expression level of serum MXRA7, and electrochemiluminescence was used to detect serum bone turnover markers (BTM) including osteocalcin (OC), type I procollagen N-terminal propeptide (PINP), and type I collagen carboxy terminal peptide beta special sequence (β-CTX) levels. Dual energy X-ray absorptiometry was used to measure bone mineral density (BMD) values of lumbar vertebrae 1~4, femoral neck, and entire hip. The observation group received comprehensive treatment according to the guidelines and was followed up for at least 1 year to calculate the incidence of fractures. Results The expression level of MXRA7 and BMD value in observation group were significantly lower than those in control group before treatment, while the levels of OC, PINP, and β-CTX were significantly higher than control group (P<0.05). Pearson test showed that the expression level of MXRA7 was significantly negatively correlated with OC, PINP, and β-CTX levels, and significantly positively correlated with BMD values (P<0.05). After follow-up in the observation group, a total of 15 cases of fractures were recorded, with an incidence rate of 14.7%. The serum MXRA7 expression level before and after treatment in the fracture subgroup were significantly lower than those in the non-fracture subgroup (P<0.05). Receiver operating characteristic (ROC) curve showed that area under curve (AUC) of MXRA7 expression before treatment for predicting fractures after treatment was 0.854 (95% CI=0.801-0.899, P<0.001). Conclusion The decrease in MXRA7 expression may be closely related to the occurrence and severity of osteoporosis in elderly patients, which can serve as a novel biomarker for predicting the risk of fracture. |
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