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| 新疆农牧区老年人UHR与肌少症相关性研究 |
| Study on the correlation between the ratio of uric acid to high-density lipoprotein cholesterol and sarcopenia in the elderly in rural and pastoral areas of Xinjiang |
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| DOI：10.3969/j.issn.1006-7108.2026.10.006 |
| 中文关键词: 肌少症 尿酸 高密度脂蛋白胆固醇 血清尿酸与高密度脂蛋白胆固醇比值 |
| 英文关键词:sarcopenia uric acid high-density lipoprotein cholesterol UHR |
| 基金项目:国家自然科学基金项目（82160276）；“天山英才”医药卫生高层次人才培养计划（TSYC202301A004） |
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| 中文摘要: |
| 目的 探讨新疆社区老年人血清尿酸（sUA）与高密度脂蛋白胆固醇（HDL-C）比值（UHR）与肌少症之间的关系。方法 选自2024年6月对“新疆纵向衰老队列”（ChiCTR2400093292）随访的数据库，共纳入476名老年人（65岁及以上）。分析UHR各组握力、步速、四肢骨骼肌肉量（ASM）、四肢骨骼肌体重比（SMI）之间差异性与相关性。通过Logistic回归模型评估UHR与肌少症之间关系，受试者工作特征（ROC）曲线分析评估UHR对肌少症的预测价值。结果 ASM、SMI、握力均数随UHR增高而增加（P＜0.05）。一般线性模型分析显示，UHR（Q3～Q4组）与握力（?=2.064）、SMI（Q3 ?=0.693，Q4 ?=0.911）呈正相关（P＜0.05），肌肉功能下降与年龄增长、女性正相关（P＜0.05）。Logistic回归分析提示，在校正BMI、HCY、Cys-C、年龄、性别、吸烟及饮酒等混杂因素后UHR高水平（Q3～Q4四分位组）肌少症风险降低（Q3：OR=0.257，95%CI： 0.108～0.612；Q4：OR=0.238，95%CI：0.092～0.616；P均≤0.003）；中等UHR水平Q2组（OR=0.605，P=0.167）、UHR作为连续变量（OR=0.997，P=0.050）在调整BMI后无统计学意义。ROC分析表明UHR在预测肌少症方面具有中等能力,其AUC为0.639（95%CI：0.570～0.708）。结论 UHR升高可能是肌肉质量与力量的保护因素。高UHR组（Q3～Q4）对肌少症的保护作用稳定且独立于BMI及HCY、Cys-C等代谢因素。 |
| 英文摘要: |
| Objective To explore the relationship between the ratio of serum uric acid (sUA) to high-density lipoprotein cholesterol (HDL-C) (UHR) and sarcopenia in the elderly in Xinjiang communities. Methods This study was a prospective one. A follow-up was conducted on the "Xinjiang Longitudinal Aging Cohort" (ChiCTR2400093292) in June 2024, involving a total of 476 elderly individuals (aged 65 and above). Analyzed the differences and correlations among grip strength, walking speed, ASM and SMI in each UHR group. Logistic regression model was used to evaluate the relationship between UHR and sarcopenia, and receiver operating characteristic (ROC) curve analysis was used to assess the predictive value of UHR for sarcopenia. Results The ASM, SMI and mean grip strength increased with the increase of UHR (P<0.05). General linear model analysis showed that UHR (Q3-Q4 groups) was positively correlated with grip strength (?=2.064) and SMI (Q3 ?=0.693, Q4 ?=0.911) (P<0.05), and muscle function decline was positively correlated with age increase and female gender (P<0.05). Logistic regression analysis indicated that after adjusting for confounding factors such as BMI, HCY, CYS-c, age, gender, smoking and drinking, a high level of UHR (Q3-Q4 quartile group) reduced the risk of sarcopenia (Q3: OR=0.257, 95% CI: 0.108-0.612;) Q4: OR=0.238, 95% CI: 0.092-0.616; All P≤0.003; The Q2 group with moderate UHR level (OR=0.605, P=0.167) and UHR as a continuous variable (OR=0.997, P=0.050) had no statistical significance after adjusting for BMI. ROC analysis indicated that UHR had a moderate ability in predicting sarcopenia, with an AUC of 0.639 (95% CI: 0.570-0.708). Conclusion Elevated UHR may be a protective factor for muscle mass and strength. The protective effect of the high UHR group (Q3-Q4) on sarcopenia was stable and independent of metabolic factors such as BMI, HCY and Cys-C. |
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