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| 针刺治疗骨质疏松症机制及临床方案 |
| Explore the mechanism and clinical protocol of acupuncture treatment for osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2026.10.009 |
| 中文关键词: 神经-内分泌-免疫网络 骨质疏松症 针刺治疗 补肾健脾通督 |
| 英文关键词:neuro-endocrine-immune network osteoporosis acupuncture Tonifying the kidney, invigorating the spleen and unblocking the governor vessel |
| 基金项目:国家自然科学基金项目（82260941，81760873）；甘肃省高校青年博士支持项目（2023QB-089）；甘肃省高等学校创新基金项目（2020A-073）；兰州市人才创新创业项目(2021-RC-101)；甘肃中医药大学科学研究与创新基金项目（2022KCZD-1） |
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| 中文摘要: |
| 骨质疏松症属于慢性增龄退行性疾病，并且在人口老龄化的背景下发病率呈每年递增的趋势，因此如何在增强疗效的前提下有效地降低其发病率以及治疗成本成为了当今亟需解决的问题。中医药文化流传至今，其丰富的理论基础为治疗临床各种疾病提供了依据并广泛运用，而针刺疗法在继承中医简便验廉特点的基础上广泛应用于骨质疏松症并取得了很好的疗效。临床显示，骨质疏松症的发病呈多脏器、多靶点致病特点，神经-内分泌-免疫功能网络与骨质疏松症的关联及针刺对该病的治疗，均基于多靶点特性。本研究旨在探讨针刺通过神经 -内分泌-免疫功能网络治疗OP的机制并优化临床取穴方案，通过结合中医“肾-脾-肝”轴与机制，分析针刺对瘦素、雌激素、肠道微生物菌群的调节作用并总结选穴规律，发现针刺可经神经、内分泌、免疫途径改善神经-内分泌-免疫功能网络失衡，主选肾俞、足三里、太溪并配合辨证配穴，从而为针刺干预OP的神经-内分泌-免疫机制提供了理论依据，并指出需结合多组学技术进一步深化研究。 |
| 英文摘要: |
| Osteoporosis is a typical modern chronic aging-related degenerative disease, and its incidence rate shows an annual increasing trend under the background of population aging. Therefore, how to effectively reduce its incidence rate and treatment cost on the premise of enhancing curative effect has become an urgent problem to be solved today. Traditional Chinese medicine (TCM) culture has been passed down to this day, and its rich theoretical foundation provides a basis for the treatment of various clinical diseases and is widely used. Acupuncture therapy, based on inheriting the characteristics of TCM being simple, effective, safe and inexpensive, is widely applied to osteoporosis and has achieved good curative effects. Clinical practice shows that osteoporosis is characterized by multi-organ and multi-target pathogenesis. Both the association between the neuro-endocrine-immune functional network and osteoporosis and the treatment of this disease by acupuncture are based on multi-target characteristics. The purpose of this study is to explore the mechanism of acupuncture in treating OP through the neuro-endocrine-immune functional network and optimize the clinical acupoint selection scheme. By combining the TCM "kidney-spleen-liver" axis with the mechanism, this study analyzes the regulatory effects of acupuncture on factors such as leptin, estrogen and IL-6, and summarizes the acupoint selection rules. It is found that acupuncture can improve the imbalance of the neuro-endocrine-immune functional network through neural, endocrine and immune pathways, mainly selecting Shenshu (BL23), Zusanli (ST36), Taixi (KI3) and cooperating with syndrome differentiation and acupoint . This provides a theoretical basis for the neuro-endocrine-immune mechanism of acupuncture intervention in OP, and points out that it is necessary to further deepen the research by combining multi-omics technology. |
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