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| 杜仲有效成分治疗骨质疏松症相关信号通路研究进展 |
| The research progress in the signaling pathways involved in the treatment of osteoporosis with active constituents from eucommia ulmoides |
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| DOI：10.3969/j.issn.1006-7108.2026.10.022 |
| 中文关键词: 杜仲 有效成分 骨质疏松 信号通路 |
| 英文关键词:eucommia ulmoides active ingredient osteoporosis signal pathway |
| 基金项目:中华中医药学会（GB_CACM_2024005）；山东省中医药科技项目（M20241721） |
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| 中文摘要: |
| 本文系统梳理并分析了近年来杜仲有效成分治疗骨质疏松症（osteoporosis，OP）的研究进展，重点总结其通过MAPK、PI3K/Akt、OPG/RANKL/RANK、BMP-2/Smad、Wnt/β-catenin等信号通路调控骨代谢的机制。结果表明，杜仲有效成分能够促进成骨细胞分化与骨形成，抑制破骨细胞生成与活性，在抗OP方面具有多靶点、低毒性的优势。然而，现有研究在机制解析上仍存在系统性不足与研究深度不够的问题。本文有助于明确杜仲有效成分防治OP的作用机制，为中医药干预OP的基础研究与临床应用提供参考。 |
| 英文摘要: |
| This study systematically reviews and analyzes recent research progress in the treatment of osteoporosis (OP) with active components from eucommia ulmoides. It particularly focuses on summarizing the mechanisms by which these constituents regulate bone metabolism through signaling pathways such as MAPK, PI3K/Akt, OPG/RANKL/RANK, BMP-2/Smad, and Wnt/β-catenin. The findings indicate that the active compounds of eucommia ulmoides promote osteoblast differentiation and bone formation and inhibit osteoclastogenesis and osteoclast activity. These constituents exhibit multi-target effects and low toxicity, presenting significant advantages in OP treatment. However, current studies still lack systematic mechanistic elucidation and sufficient depth. This review helps clarify the mechanisms underlying the anti-osteoporotic effects of eucommia ulmoides, providing a theoretical basis for further basic research and clinical application of traditional Chinese medicine in OP intervention. |
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